{"created":"2023-08-28T05:05:12.907596+00:00","id":2000034,"links":{},"metadata":{"_buckets":{"deposit":"54e3acf2-0f25-4450-bbad-296a7da1259c"},"_deposit":{"created_by":5,"id":"2000034","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"2000034"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000034","sets":["74","74:26"]},"author_link":["33890","27778"],"control_number":"2000034","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"105695","bibliographic_titles":[{"bibliographic_title":"Antiviral Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Orthohepadnavirus genus includes hepatitis B virus (HBV) that can cause chronic hepatitis and hepatocarcinoma in humans. Recently, a novel hepadnavirus in cats, domestic cat hepadnavirus (DCH), was identified that is genetically close to HBV. DCH infection is associated with chronic hepatitis in cats, suggesting a similarity with HBV pathogenesis and the potential to use DCH as a novel animal model for HBV research. HBV is shown to use the sodium/bile acid cotransporter (NTCP) as a major cell entry receptor, but the equivalent receptor for DCH remains unknown. Here we sought to identify the entry receptor for DCH. HBV- and DCH-derived preS1 peptides efficiently bound to both human and cat NTCPs, and residue 158 of NTCP proteins determined the species-specific binding of the DCH preS1 peptide. Myrcludex B, an HBV entry inhibitor, blocked the binding of the DCH preS1 peptide. Thus, DCH and HBV may share cell entry molecules, suggesting a possibility of inter-species transmission. Furthermore, our study suggests that DHC can be useful as a novel model for HBV research.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.antiviral.2023.105695","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"en","subitem_relation_name_text":"Publisher’s web site"}],"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.antiviral.2023.105695","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Authors. Published by Elsevier B.V.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01663542","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shofa, Maya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohkawa, Akiho","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"金子, 泰之","creatorNameLang":"ja"},{"creatorName":"カネコ, ヤスユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kaneko, Yasuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"金子","familyNameLang":"ja"},{"familyName":"カネコ","familyNameLang":"ja-Kana"},{"familyName":"Kaneko","familyNameLang":"en"}],"givenNames":[{"givenName":"泰之","givenNameLang":"ja"},{"givenName":"ヤスユキ","givenNameLang":"ja-Kana"},{"givenName":"Yasuyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27778","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80782945","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80782945"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"齊藤, 暁","creatorNameLang":"ja"},{"creatorName":"サイトウ, アカツキ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Akatsuki ","creatorNameLang":"en"}],"familyNames":[{"familyName":"齊藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"},{"familyName":"Saito","familyNameLang":"en"}],"givenNames":[{"givenName":"暁","givenNameLang":"ja"},{"givenName":"アカツキ","givenNameLang":"ja-Kana"},{"givenName":"Akatsuki ","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33890","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30621792","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30621792"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-28"}],"filename":"1-s2.0-S0166354223001730-main.pdf","filesize":[{"value":"9.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://miyazaki-u.repo.nii.ac.jp/record/2000034/files/1-s2.0-S0166354223001730-main.pdf"},"version_id":"4ee3c148-f149-4c53-b95d-01b64901c882"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hepadnavirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatitis B virus (HBV)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Domestic cat hepadnavirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sodium/bile acid cotransporter (NTCP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-02"},"publish_date":"2023-08-02","publish_status":"0","recid":"2000034","relation_version_is_last":true,"title":["Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-15T04:55:04.817976+00:00"}