{"created":"2023-05-15T09:57:46.381849+00:00","id":1615,"links":{},"metadata":{"_buckets":{"deposit":"58a3486d-eabf-4c94-ac61-84489df0158c"},"_deposit":{"created_by":5,"id":"1615","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1615"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001615","sets":["72","72:30"]},"author_link":["7909","7907","7906","7905","7904"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Suppl February","bibliographicPageEnd":"S78","bibliographicPageStart":"S71","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adrenomedullin （AM） and peptides of the proadrenomedullin N-terminal 20 peptide\n（PAMP20） family are multifunctional peptides abundantly expressed in the adrenal medulla. These\npeptides are released by regulated exocytosis along with catecholamines upon stimulation of adrenal\nchromaffin cells. They are also released gradually during culture, and this release is stimulated by a\ncyclic AMP-dependent pathway. The expression and release of AM increase under hypoxia in\nchromaffin cells. The expression of AM in pheochromocytoma PC12 cells is reduced during neuronal\ndifferentiation with nerve growth factor. On the other hand, PAMP20 and PAMP12 suppress\ncatecholamine release and synthesis by interfering with nicotinic cholinergic receptors. AM increases\nblood flow in the adrenal gland, and causes a gradual release of catecholamine, but does not modify\nregulated exocytosis upon the stimulation of cells.\nCurrent data indicate that the expression of these peptides is regulated by intracellular\nsignaling pathways, and changes under various physiological and pathological conditions. AM and\nPAMP20 family peptides have distinct physiological functions. PAMP20 and PAMP12 are\nendogenous peptides that modulate chromaffin cell function in an autocrine manner, whereas AM may\nmainly regulate vascular cell function in a paracrine manner.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Hypertension","subitem_publisher_language":"en"},{"subitem_publisher":"日本高血圧学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10847079","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09169636","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 英幸","creatorNameLang":"ja"},{"creatorName":"コバヤシ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Hideyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7904","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"柳田, 俊彦","creatorNameLang":"ja"},{"creatorName":"ヤナギタ, トシヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yanagita, Toshihiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"柳田","familyNameLang":"ja"},{"familyName":"ヤナギタ","familyNameLang":"ja-Kana"},{"familyName":"Yanagita","familyNameLang":"en"}],"givenNames":[{"givenName":"俊彦","givenNameLang":"ja"},{"givenName":"トシヒコ","givenNameLang":"ja-Kana"},{"givenName":"Toshihiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7906","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60295227","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60295227"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"横尾, 宏毅","creatorNameLang":"ja"},{"creatorName":"ヨコオ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoo, Hiroki","creatorNameLang":"en"}],"familyNames":[{"familyName":"横尾","familyNameLang":"ja"},{"familyName":"ヨコオ","familyNameLang":"ja-Kana"},{"familyName":"Yokoo","familyNameLang":"en"}],"givenNames":[{"givenName":"宏毅","givenNameLang":"ja"},{"givenName":"ヒロキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田, 明彦","creatorNameLang":"ja"},{"creatorName":"ワダ, アキヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7907","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"横尾, 宏毅","creatorNameLang":"ja"},{"creatorName":"ヨコオ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoo, Hiroki","creatorNameLang":"en"}],"familyNames":[{"familyName":"横尾","familyNameLang":"ja"},{"familyName":"ヨコオ","familyNameLang":"ja-Kana"},{"familyName":"Yokoo","familyNameLang":"en"}],"givenNames":[{"givenName":"宏毅","givenNameLang":"ja"},{"givenName":"ヒロキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wada, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7909","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"hypertes_res_26suppl_s71_s78_2003.pdf","filesize":[{"value":"436.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Hypertes Res 26suppl s71-s78,2003.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1615/files/hypertes_res_26suppl_s71_s78_2003.pdf"},"version_id":"f19d9de2-d117-4f00-8498-bb8e7e1961e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adrenomedullin, proadrenomedullin N-terminal peptides, chromaffin cells, cholinergic receptors, hypoxia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-04-09"},"publish_date":"2008-04-09","publish_status":"0","recid":"1615","relation_version_is_last":true,"title":["Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2025-01-07T02:39:00.853848+00:00"}