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Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells
http://hdl.handle.net/10458/1511
http://hdl.handle.net/10458/1511f28905c2-f132-4f33-afb2-863d977bfc93
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hypertes Res 26suppl s71-s78,2003.pdf (436.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-04-09 | |||||
| タイトル | ||||||
| タイトル | Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | adrenomedullin, proadrenomedullin N-terminal peptides, chromaffin cells, cholinergic receptors, hypoxia | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
小林, 英幸
× 小林, 英幸× 柳田, 俊彦× 横尾, 宏毅× 和田, 明彦× 横尾, 宏毅× Wada, Akihiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Adrenomedullin （AM） and peptides of the proadrenomedullin N-terminal 20 peptide （PAMP20） family are multifunctional peptides abundantly expressed in the adrenal medulla. These peptides are released by regulated exocytosis along with catecholamines upon stimulation of adrenal chromaffin cells. They are also released gradually during culture, and this release is stimulated by a cyclic AMP-dependent pathway. The expression and release of AM increase under hypoxia in chromaffin cells. The expression of AM in pheochromocytoma PC12 cells is reduced during neuronal differentiation with nerve growth factor. On the other hand, PAMP20 and PAMP12 suppress catecholamine release and synthesis by interfering with nicotinic cholinergic receptors. AM increases blood flow in the adrenal gland, and causes a gradual release of catecholamine, but does not modify regulated exocytosis upon the stimulation of cells. Current data indicate that the expression of these peptides is regulated by intracellular signaling pathways, and changes under various physiological and pathological conditions. AM and PAMP20 family peptides have distinct physiological functions. PAMP20 and PAMP12 are endogenous peptides that modulate chromaffin cell function in an autocrine manner, whereas AM may mainly regulate vascular cell function in a paracrine manner. |
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| 言語 | en | |||||
| 書誌情報 |
en : Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 巻 26, 号 Suppl February, p. S71-S78, 発行日 2003-02 |
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| 出版者 | ||||||
| 出版者 | Japanese Society of Hypertension | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本高血圧学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09169636 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10847079 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
