@article{oai:miyazaki-u.repo.nii.ac.jp:00001579,
 author = {小川, 恒夫 and 今村, 卓郎 and Imamura, Takuroh and Kitamura, Kazuo and 北村, 和雄 and Ogawa, Tsuneo and 今村, 卓郎 and Imamura, Takuroh},
 issue = {4},
 journal = {生物試料分析, Journal of Analytical Bio-Science},
 month = {Sep},
 note = {Obesity is a chronic state in which adipocytes store excess fat, macrophages infiltrate adipose tissue, and adipocytes together with the stromal vascular fraction display inflammatory activities, which form the basis of metabolic syndrome （MetS）. Because various cells including macrophages, endothelial cells, fibroblasts and adipocytes produce pentraxin 3 （PTX3） in response to inflammatory stimuli, PTX3 might be involved in the pathogenesis of obesity and MetS. Among four articles investigating plasma PTX3 in MetS or obesity, three have reported a decrease in plasma PTX3 in MetS or obesity subjects. The stimulatory effect of high-density lipoprotein cholesterol on PTX3 gene might partially explain the decrease in plasma PTX3 in MetS. As there is abundant evidence that PTX3 possesses tissue-protective and anti-inflammatory effects, a decrease of plasma PTX3 in MetS or obesity might be the result of PTX3 consumption or might be involved in the development of the disease; however, the precise mechanism of the adipose tissue-derived PTX3 contribution to chronic inflammatory disease remains to be clarified.},
 pages = {339--346},
 title = {メタボリック症候群とペントラキシン3},
 volume = {33},
 year = {2010},
 yomi = {オガワ, ツネオ and イマムラ, タクロウ and キタムラ, カズオ and イマムラ, タクロウ}
}