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Detection of COL1A1-PDGFB fusion transcripts and PDGF α-and β-Receptors in giant cell fibroblastoma of the postsacrococcygeal region
http://hdl.handle.net/10458/1374
http://hdl.handle.net/10458/13746e5a36c8-d167-4b42-89d6-2e43d3e209d2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
asada brjouderma154(5)2006.pdf (329.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-03-17 | |||||
| タイトル | ||||||
| タイトル | Detection of COL1A1-PDGFB fusion transcripts and PDGF α-and β-Receptors in giant cell fibroblastoma of the postsacrococcygeal region | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Giant cell fibroblastoma, COL1A1-PDGFB fusion transcripts, PDGFα-and β-receptors | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kashima, A.
× Kashima, A.× Yamashita, A.× Moriguchi, S.× Marutsuka, K.× Tsumori, S.× Yoshizato, K.× Ishihara, A.× Setoyama, M.× 浅田, 祐士郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We describe a case of recurrent giant cell fibroblastoma （GCF） of the postsacrococcygeal region in a 2-year-old girl. Both the initial and recurrent tumors contained solid and angiectoid areas. The former was composed of loosely arranged wavy spindle cells and giant cells with a well vascularized myxoid to collagenous stroma. The angiectoid spaces were often lined by multinucleated giant cells. Immunohistochemically, the tumor cells and small vessels in the tumor tissue were positive for platelet derived growth factor （PDGF）α- andβ-receptors. Molecular analysis revealed fusion of collagen type Iα1 exon 26 with PDGF-B chain exon 2 that induced unscheduled production of PDGF-BB. These findings suggest that PDGF and its receptors significantly contribute to the development of GCF in an autocrine and a paracrine manner. |
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| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The definitive version is available at www.blackwell-synergy.com | |||||
| 言語 | en | |||||
| 書誌情報 |
en : British journal of dermatology : official organ of British Association of Dermatologists 巻 154, 号 5, p. 983-987, 発行日 2006-05 |
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| 出版者 | ||||||
| 出版者 | Blackwell Publishing | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00070963 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00574479 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
