@article{oai:miyazaki-u.repo.nii.ac.jp:00001531.1, author = {浅田, 祐士郎 and Asada, Yujiro and Nishihira, Kensaku and Imamura, Takuroh and Hatakeyama, Kinta and Yamashita, Atsushi and Shibata, Yoshisato and Date, Haruhiko and Manabe, Ichiro and Nagai, Ryozo and Kitamura, Kazuo}, issue = {2}, journal = {Thrombosis research}, month = {}, note = {Interleukin (IL)-18 plays a central role in the inflammatory cascade. We immunohistochemically assessed specimens obtained by directional coronary atherectomy (DCA) from patients with stable and unstable angina to determine whether IL-18 expression in coronary atherosclerotic lesions is related to plaque instability. We detected IL-18 immunoreactivity in coronary culprit plaques, especially in macrophages. More areas were immunopositive for IL-18 in DCA specimens from patients with unstable angina than in those with stable angina and IL-18 expression was increased in plaques containing thrombus. Furthermore, IL-18 expression significantly correlated with IFN-ホウ expression. These findings suggest that IL-18 is involved in the pathogenesis of plaque instability in human coronary arteries., http://www.elsevier.com/wps/find/journaldescription.cws_home/369/description}, pages = {275--279}, title = {Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina}, volume = {121}, year = {2007}, yomi = {アサダ , ユウジロウ} }