{"created":"2023-05-15T09:57:41.503985+00:00","id":1529,"links":{},"metadata":{"_buckets":{"deposit":"6801e2bb-8ff4-4372-9275-203744510ae8"},"_deposit":{"created_by":5,"id":"1529","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1529"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001529","sets":["72","72:30"]},"author_link":["8019","9078","8383","8315"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1298","bibliographicPageStart":"1293","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"臨床精神医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Japanese journal of clinical psychiatry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年, 薬物治療抵抗性うつ病や精神病性うつ病に対して, 抗うつ薬と第二世代抗精神病薬の併用の有用性を示唆する報告が散見される｡  今回われわれは, 三環系, 四環系, SSRI, SNRIなどの抗うつ薬により, 抑うつ症状が改善せず年単位で遷延した症例に対して, 第二世代抗精神病薬のperospironeを追加投与することにより, うつ病の抑うつ症状や身体症状が改善した2症例を経験した。perospironeは強力な5-HT_2A受容体拮抗作用と中程度の5-HT_1A受容体作動作用を有し, 不安や抑うつ症状を改善させる作用が示されており, 治療困難なうつ病に対して, perospironeによる増強療法が有効である可能性が示唆された｡","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"アークメディア","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00253400","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300032X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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ヤスシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ishida","familyNameLang":"en"},{"familyName":"石田","familyNameLang":"ja"},{"familyName":"イシダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasushi","givenNameLang":"en"},{"givenName":"康","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8383","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20212897","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20212897"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"精神病性うつ病, 治療抵抗性うつ病, ペロスピロン, 増強療法, 高齢患者","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"psychotic depression, treatment-resistant depression, perospirone, augmentation therapy, elderly patients","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗うつ薬とperospironeによる増強療法が奏功した薬物治療抵抗性うつ病の2症例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗うつ薬とperospironeによる増強療法が奏功した薬物治療抵抗性うつ病の2症例","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-01-08"},"publish_date":"2010-01-08","publish_status":"0","recid":"1529","relation_version_is_last":true,"title":["抗うつ薬とperospironeによる増強療法が奏功した薬物治療抵抗性うつ病の2症例"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-07T04:34:27.463939+00:00"}