{"created":"2023-05-15T11:52:07.311459+00:00","links":{},"metadata":{"_buckets":{"deposit":"cc265da5-f384-493c-a31a-4c5a14de4a25"},"_deposit":{"id":"1514.1","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1514.1"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001514.1","sets":["72:30"]},"author_link":["8738"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-01-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"102(102)","bibliographicPageStart":"98(98)","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"脳21","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小胞体ストレスは神経変性疾患の発症に密接に関わることが示唆されており,治療法開発には小胞体ストレス応答の全貌解明が必要である.我々は小胞体ストレスに対し強い抵抗性を示すアストロサイトに注目し,その細胞で特異的に発現する新規小胞体ストレスセンサーOASISの同定に成功した.OASISは,膜貫通型転写因子で小胞体ストレスに反応して膜内切断を受ける.切断断片は核に移行し小胞体分子シャペロンBiP/GRP78の転写を促すことでアポトーシスから細胞を保護する.このようなOASISの機能はアストロサイトのみで発揮されることから,｢細胞種特異的な小胞体ストレス応答機構｣という新しい概念が浮び上がってきた.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金芳堂","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11217870","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13440128","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今泉, 和則","creatorNameLang":"ja"},{"creatorName":"イマイズミ, カズノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8738","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"S-8_imaizumi-nou21-2006.pdf","filesize":[{"value":"760.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-8_imaizumi-nou21-2006.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1514.1/files/S-8_imaizumi-nou21-2006.pdf"},"version_id":"ab8d4f81-4229-424d-95ff-6742e28a2386"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小胞体ストレス, アストロサイト, 転写因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"unfolded protein response, OASIS","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"グリア細胞の小胞体ストレス応答を制御する膜貫通型転写因子OASIS : 新規小胞体ストレスセンサーOASISの活性制御機構と機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"グリア細胞の小胞体ストレス応答を制御する膜貫通型転写因子OASIS : 新規小胞体ストレスセンサーOASISの活性制御機構と機能","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-09"},"publish_date":"2009-10-09","publish_status":"0","recid":"1514.1","relation_version_is_last":true,"title":["グリア細胞の小胞体ストレス応答を制御する膜貫通型転写因子OASIS : 新規小胞体ストレスセンサーOASISの活性制御機構と機能"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2025-06-01T23:48:22.811016+00:00"}