{"created":"2023-05-15T09:57:40.661442+00:00","id":1511,"links":{},"metadata":{"_buckets":{"deposit":"ed0c6614-c544-4c53-b692-6ecbcb1ef1c2"},"_deposit":{"created_by":5,"id":"1511","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1511"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001511","sets":["72","72:30"]},"author_link":["8738"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"15(299)","bibliographicPageStart":"9(293)","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"脳21","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"捕乳動物の細胞は実に多彩な機能と形態を保有する.タンパク質を活発に分泌する細胞では小胞体の発達が著しい.このような細胞では大量のタンパク質合成と修飾のため常に小胞体に負荷がかかる状態（小胞体ストレス）にある.そのためタンパク質のフォールディンクおよび異常タンパク質の排除をより円滑に行うシステムが備わっている.筆者らは特定の細胞のみで小胞体ストレスから回避する応答系､すなわちunfolde protein responseの活性化に寄与する新規膜結合型転写因子OASISを見つけ出すことに成功した.本稿ではOASISの機能解析を通して見えてきた組織あるいは細胞種特異的小胞体ストレス応答の概略を述べる.さらに小胞体ストレスが負荷された際に､オートファジーが活性化して小胞体ストレスから保護することを明らかにしたので､その解析結果も併せて紹介する.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金芳堂","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11217870","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13440128","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今泉, 和則","creatorNameLang":"ja"},{"creatorName":"イマイズミ, カズノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8738","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"S-20_imaizumi-nou21-2008.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-20_imaizumi-nou21-2008.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1511/files/S-20_imaizumi-nou21-2008.pdf"},"version_id":"2cdb9f27-a874-4e16-9406-e62962c99a27"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小胞体ストレス, 膜貫通型転写因子, アストロサイト, オートファジー, 神経変性疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"小胞体ストレス応答の多様性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小胞体ストレス応答の多様性","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-10-09"},"publish_date":"2009-10-09","publish_status":"0","recid":"1511","relation_version_is_last":true,"title":["小胞体ストレス応答の多様性"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2025-06-01T23:45:31.890855+00:00"}