{"created":"2023-05-15T09:57:39.499833+00:00","id":1493,"links":{},"metadata":{"_buckets":{"deposit":"fdcf39fc-6c80-4bc5-9750-25a2256c5b38"},"_deposit":{"created_by":5,"id":"1493","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1493"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001493","sets":["72","72:30"]},"author_link":["8871","8866","8862","8867","9145","8755","8869","8870","8859","8751","8738","8868","8814","8787"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"24","bibliographicPageEnd":"9231","bibliographicPageStart":"9220","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Molecular and cellular biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Eukaryotic cells deal with accumulation of unfolded proteins in the endoplasmic reticulum （ER） by the unfolded protein response, involving the induction of molecular chaperones, translational attenuation, and ER-associated degradation, to prevent cell death. Here, we found that the autophagy system is activated as a novel signaling pathway in response to ER stress. Treatment of SK-N-SH neuroblastoma cells with ER stressors markedly induced the formation of autophagosomes, which were recognized at the ultrastructural level. The formation of green fluorescent protein （GFP）-LC3-labeled structures （GFP-LC3 “dots\"）, representing autophagosomes, was extensively induced in cells exposed to ER stress with conversion from LC3-I to LC3-II. In IRE1-deficient cells or cells treated with c-Jun N-terminal kinase （JNK） inhibitor, the autophagy induced by ER stress was inhibited, indicating that the IRE1-JNK pathway is required for autophagy activation after ER stress. In contrast, PERK-deficient cells and ATF6 knockdown cells showed that autophagy was induced after ER stress in a manner similar to the wild-type cells. Disturbance of autophagy rendered cells vulnerable to ER stress, suggesting that autophagy plays important roles in cell survival after ER stress.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Copyright © 2009, American Society for Microbiology. All Rights Reserved.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology","subitem_publisher_language":"en"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10620925","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02707306","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogata, Maiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8859","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Hino, Shin-ichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hino","familyNameLang":"en"}],"givenNames":[{"givenName":"Shin-ichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8814","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"斎藤, 敦","creatorNameLang":"ja"},{"creatorName":"サイトウ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"斎藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"},{"familyName":"Saito","familyNameLang":"en"}],"givenNames":[{"givenName":"敦","givenNameLang":"ja"},{"givenName":"アツシ","givenNameLang":"ja-Kana"},{"givenName":"Atsushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morikawa, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8862","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"近藤, 慎一","creatorNameLang":"ja"},{"creatorName":"コンドウ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Shinichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"近藤","familyNameLang":"ja"},{"familyName":"コンドウ","familyNameLang":"ja-Kana"},{"familyName":"Kondo","familyNameLang":"en"}],"givenNames":[{"givenName":"慎一","givenNameLang":"ja"},{"givenName":"シンイチ","givenNameLang":"ja-Kana"},{"givenName":"Shinichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8751","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Kanemoto, Soshi","creatorNameLang":"en"},{"creatorName":"金本, 聡自","creatorNameLang":"ja"},{"creatorName":"カネモト, ソウシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Kanemoto","familyNameLang":"en"},{"familyName":"金本","familyNameLang":"ja"},{"familyName":"カネモト","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Soshi","givenNameLang":"en"},{"givenName":"聡自","givenNameLang":"ja"},{"givenName":"ソウシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Tomohiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniguchi, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanii, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinaga, Kazuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiosaka, Sadao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hammarback, A.  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