{"created":"2023-07-29T23:10:11.417196+00:00","links":{},"metadata":{"_buckets":{"deposit":"918e15a5-0523-484b-849e-fb0b1d3c864b"},"_deposit":{"created_by":9,"id":"1493.3","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1493.3"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001493.3","sets":["72","72:30"]},"author_link":["8859","8814","8861","8862","8863","8864","8755","8866","8867","8868","8869","8870","8871","8738"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"24","bibliographicPageEnd":"9231","bibliographicPageStart":"9220","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Molecular and cellular biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Eukaryotic cells deal with accumulation of unfolded proteins in the endoplasmic reticulum （ER） by the unfolded protein response, involving the induction of molecular chaperones, translational attenuation, and ER-associated degradation, to prevent cell death. Here, we found that the autophagy system is activated as a novel signaling pathway in response to ER stress. Treatment of SK-N-SH neuroblastoma cells with ER stressors markedly induced the formation of autophagosomes, which were recognized at the ultrastructural level. The formation of green fluorescent protein （GFP）-LC3-labeled structures （GFP-LC3 “dots\"）, representing autophagosomes, was extensively induced in cells exposed to ER stress with conversion from LC3-I to LC3-II. In IRE1-deficient cells or cells treated with c-Jun N-terminal kinase （JNK） inhibitor, the autophagy induced by ER stress was inhibited, indicating that the IRE1-JNK pathway is required for autophagy activation after ER stress. In contrast, PERK-deficient cells and ATF6 knockdown cells showed that autophagy was induced after ER stress in a manner similar to the wild-type cells. Disturbance of autophagy rendered cells vulnerable to ER stress, suggesting that autophagy plays important roles in cell survival after ER stress.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Copyright © 2009, American Society for Microbiology. All Rights Reserved.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology","subitem_publisher_language":"en"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10620925","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02707306","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogata, Maiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hino, Shin-ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morikawa, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanemoto, Soshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Tomohiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniguchi, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanii, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinaga, Kazuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiosaka, Sadao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hammarback, A.  James","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8870","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Urano, Fumihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imaizumi, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8738","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"9220-1.pdf","filesize":[{"value":"746.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"9220[1].pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1493/files/9220-1.pdf"},"version_id":"16d214a7-5b00-4249-b2ea-c31a45b64aa0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-09-28"},"publish_date":"2009-09-28","publish_status":"0","recid":"1493.3","relation_version_is_last":true,"title":["Autophagy is activated for cell survival after endoplasmic reticulum stress"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-06-01T23:46:10.037875+00:00"}