{"created":"2023-05-15T09:57:38.777947+00:00","id":1482,"links":{},"metadata":{"_buckets":{"deposit":"eb1748c4-cf88-48ba-9d75-8f5dd146df7a"},"_deposit":{"created_by":5,"id":"1482","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1482"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001482","sets":["72","72:30"]},"author_link":["8763","8738","8765","8766","8768"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-04-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"67","bibliographicPageStart":"63","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"日本神経精神薬理学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Japanese journal of psychopharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小胞体（ER）ストレスは,折りたたみ不整な蛋白が細胞内に蓄積することによって生じ,アルツハイマー病などの神経変性疾患の病理過程に関与しているとされる.ERストレスに対し,細胞は反応機構を元来備えており,ストレス状況からの離脱を図る.本研究はERストレス反応機構の1つである分子シャペロン誘導を人為的に行い,ストレスからの離脱を図ることで,アルツハイマー病（AD）などの神経変性疾患の治療に応用しようとするものである.分子シャペロンBiPのプロモーターを用いた解析から,我々はBiP誘導剤（BIX:BiPinducerX）を得た.細胞実験から,BIXはBiPのみ誘導し,他のERストレス反応分子を誘導させないことが示された.また,BIXで処理した細胞はERストレスに耐性を示し,ERのアポトーシス誘導分子の発現を抑えることが示された.さらに,マウスの脳室にBIXを前投与し,脳虚血を負荷すると梗塞巣の面積の減少をもたらし,神経症状の軽減が認められた.このBIXの効果は,梗塞周辺領域でERのアポトーシス誘導分子の発現を抑えることによることが示された.以上のように,BIXはERストレスから生じるアポトーシスを抑制し,ADをはじめとする神経変性疾患の治療薬になることが示唆された.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本神経精神薬理学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10437793","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13402544","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"工藤, 喬","creatorNameLang":"ja"},{"creatorName":"クドウ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今泉, 和則","creatorNameLang":"ja"},{"creatorName":"イマイズミ, カズノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Imaizumi, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原, 英彰","creatorNameLang":"ja"},{"creatorName":"ハラ, ヒデアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kudo, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"S-15imaizumi-jpn.j.neuropsychopharmacol-2007.pdf","filesize":[{"value":"937.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-15imaizumi-jpn.j.neuropsychopharmacol-2007.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1482/files/S-15imaizumi-jpn.j.neuropsychopharmacol-2007.pdf"},"version_id":"68707e1a-f7bc-4eaa-9c7b-118ae72235b7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小胞体(ER)ストレス, 分子シャペロン, アポトーシス, 脳虚血, 神経変性疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ER stress, Molecular chaperone, Apoptosis, Cerebral ischemia, Neurodegenerative diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"分子シャペロン誘導剤の神経変性疾患治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子シャペロン誘導剤の神経変性疾患治療への応用","subitem_title_language":"ja"},{"subitem_title":"A molecular chaperone inducer as potential therapeutic agent for neurodegenerative diseases","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"1482","relation_version_is_last":true,"title":["分子シャペロン誘導剤の神経変性疾患治療への応用"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2024-01-30T04:26:55.353752+00:00"}