{"created":"2023-05-15T09:57:38.348763+00:00","id":1474,"links":{},"metadata":{"_buckets":{"deposit":"8eb69bc2-199a-4b8c-9bf2-97c19a3f1d9f"},"_deposit":{"created_by":5,"id":"1474","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1474"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001474","sets":["72","72:30"]},"author_link":["8738"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"37(351)","bibliographicPageStart":"31(345)","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"血管医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Vascular biology & medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膜結合型タンパク質あるいは分泌型タンパク質は小胞体内に一旦運び込まれ,様々な修飾を受けて機能をもったタンパク質に成熟していく.この過程で細胞内外からの様々な刺激によりタンパク質の成熟が阻害され,小胞体（endoplasmic reticulum ; ER）内に不良タンパク質（unfolded protein）が過剰に蓄積し,細胞にダメージを与える（ERストレス）.細胞にとってER機能異常は極めて重篤な事態で,直ちにストレスから回避するための防御システムを活性化させる.この応答系をERストレス応答あるいはunfolded protein response （UPR）と呼び,酵母から哺乳細胞に至るまで真核細胞に広く保存されている.ER内タンパク品質管理の障害が脳神経疾患や糖尿病,骨軟骨疾患などの数多くの疾患に密接に関わることがわかってきた.本稿ではERストレスがどのような機序で各疾患を発症させているのか,これまで明らかにされてきた分子機構について紹介する.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"メディカルレビュー社","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11486770","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13459031","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今泉, 和則","creatorNameLang":"ja"},{"creatorName":"イマイズミ, カズノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8738","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"s-22_imaizumi-kekkanigaku-2008.pdf","filesize":[{"value":"754.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-22_ imaizumi-kekkanigaku-2008.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1474/files/s-22_imaizumi-kekkanigaku-2008.pdf"},"version_id":"0a69fca6-a0a9-4d62-b985-47c93a0f21a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小胞体(ER)ストレス, 骨軟骨疾患, 脳神経疾患, 疾患治療, 糖尿病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"疾患とERストレス","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"疾患とERストレス","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"1474","relation_version_is_last":true,"title":["疾患とERストレス"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2024-05-27T04:05:59.492680+00:00"}