{"created":"2023-05-15T09:57:38.218937+00:00","id":1471,"links":{},"metadata":{"_buckets":{"deposit":"ad1aa5a9-f708-4452-88f3-f9c3082049d0"},"_deposit":{"created_by":5,"id":"1471","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1471"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001471","sets":["72","72:30"]},"author_link":["8738"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicPageEnd":"2293","bibliographicPageStart":"2287","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"蛋白質・核酸・酵素","bibliographic_titleLang":"ja"},{"bibliographic_title":"Protein, nucleic acid and enzyme","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ゲノム情報を正確に蛋白質翻訳に変換していく過程で,スプライシングは重要なステップになっている.多種多様な遺伝子のイントロンとエキソンを認識して忠実にイントロン部分のみを切断し,さらにはエキソンどうしを精密に結合させる.本来精密であるべきスプライシング機構に異常が生じた場合,機能を欠いた蛋白質あるいは細胞傷害性の異常蛋白質が産生され,時として疾患発症に結びつく.本稿では巧妙に制御されたスプライシングの分子機構とそれが破綻したときに生じる疾患の発症機序について紹介する.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"共立出版","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00140437","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00399450","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今泉, 和則","creatorNameLang":"ja"},{"creatorName":"イマイズミ, カズノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Imaizumi, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8738","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"S-11_imaizumi_protein-vol.51-2006.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-11_imaizumi_protein-vol.51-2006.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1471/files/S-11_imaizumi_protein-vol.51-2006.pdf"},"version_id":"83aa33d4-765e-42fb-ba0d-9c2278b2424f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"スプライシング, 疾患, FTDP, 脊髄性筋委縮症, 筋強直性ジストロフィー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"RNAスプライシング異常と難治性疾患","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNAスプライシング異常と難治性疾患","subitem_title_language":"ja"},{"subitem_title":"Aberrant mRNA splicing in human diseases","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"1471","relation_version_is_last":true,"title":["RNAスプライシング異常と難治性疾患"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2024-05-27T04:05:58.726595+00:00"}