{"created":"2023-05-15T09:57:34.526895+00:00","id":1398,"links":{},"metadata":{"_buckets":{"deposit":"683938d1-25c5-4e19-83a5-33e83fa48306"},"_deposit":{"created_by":5,"id":"1398","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1398"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001398","sets":["72","72:30"]},"author_link":["8229","8228","7727","8035","8016","8036","8230","8037","6574"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"70","bibliographicPageStart":"67","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"磁気共鳴と医学","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To analyze the hippocampal anti-oxydant ability in the Fe-induced epilepsy model, microdialysis was used to monitor the sequential changes of an exogenous nitroxide radical by X-band ESR in the freely moving rats. Nitroxide radicals used in this study are 200mM 3-methoxy carbonyl-2,2,5,5-tetramethylpyrrolidine-l-oxyl （PCAM） i.p. administration and 300mM 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-l-oxyl（carbamoyl-PROXYL） perfusated into the hippocampus for 70 min at 3ul/min. Each half-life of carbamoyl-PROXYL and PCAM in the epilepsy model was statistically longer than that of control, respectively. Prolonged half-life of carbamoyl-PROXYL reveals the decreased antioxydant ability in the extracellular space （ascorbic acid）, while prolonged half-life of PCAM indicates the decreased anti-oxydant ability in the neuronal membrane （ascorbic acid and α-tocopherol）. The result of the decreased hippocampal anti-oxydant ability is possibly due to lipid peroxidation induced by the repetitive seizures, and the decreased aniti-oxydant ability will results in the more severe damage in the pyramidal cell of the hippocampus.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本医学館","subitem_publisher_language":"ja"},{"subitem_publisher":"Magnetic resonance in medicine","subitem_publisher_language":"en"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10217072","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土井, 拓","creatorNameLang":"ja"},{"creatorName":"ドイ, タク","creatorNameLang":"ja-Kana"},{"creatorName":"Doi, Taku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8228","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"植田, 勇人","creatorNameLang":"ja"},{"creatorName":"ウエダ, ユウト","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Yuto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 暉","creatorNameLang":"ja"},{"creatorName":"ナカジマ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakajima, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横山, 秀克","creatorNameLang":"ja"},{"creatorName":"ヨコヤマ, ヒデカツ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoyama, Hidekatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳丸, 潤","creatorNameLang":"ja"},{"creatorName":"トクマル, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Tokumaru, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三山, 吉夫","creatorNameLang":"ja"},{"creatorName":"ミツヤマ, ヨシオ","creatorNameLang":"ja-Kana"},{"creatorName":"Mitsuyama, Yoshio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8230","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"保田, 昌秀","creatorNameLang":"ja"},{"creatorName":"ヤスダ, マサヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Masahide","creatorNameLang":"en"}],"familyNames":[{"familyName":"保田","familyNameLang":"ja"},{"familyName":"ヤスダ","familyNameLang":"ja-Kana"},{"familyName":"Yasuda","familyNameLang":"en"}],"givenNames":[{"givenName":"昌秀","givenNameLang":"ja"},{"givenName":"マサヒデ","givenNameLang":"ja-Kana"},{"givenName":"Masahide","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6574","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Ohya, Hiroaki","creatorNameLang":"en"},{"creatorName":"Ohya-Nishiguchi, Hiroaki","creatorNameLang":"en"},{"creatorName":"大矢, 博明","creatorNameLang":"ja"},{"creatorName":"オオヤ, ヒロアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ohya","familyNameLang":"en"},{"familyName":"Ohya-Nishiguchi","familyNameLang":"en"},{"familyName":"大矢","familyNameLang":"ja"},{"familyName":"オオヤ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"},{"givenName":"Hiroaki","givenNameLang":"en"},{"givenName":"博明","givenNameLang":"ja"},{"givenName":"ヒロアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 仁","creatorNameLang":"ja"},{"creatorName":"カマダ, ヒトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamada, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8037","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"2-17b_ueda-jiki-vol.11-2000.pdf","filesize":[{"value":"332.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2-17b_ueda-jiki-vol.11-2000.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1398/files/2-17b_ueda-jiki-vol.11-2000.pdf"},"version_id":"304fc206-328d-4810-824d-8bb6dd3a34fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Epilepsy, ESR, nitroxide radical, in vivo microdialysis, anti-oxydant ability","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"鉄塩誘導てんかんモデルラットの無麻酔自由行動条件下における海馬抗酸化能力の減弱 : 無麻酔自由行動条件下でのX-band ESRを用いた検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"鉄塩誘導てんかんモデルラットの無麻酔自由行動条件下における海馬抗酸化能力の減弱 : 無麻酔自由行動条件下でのX-band ESRを用いた検討","subitem_title_language":"ja"},{"subitem_title":"Anti-oxydant ability in the hippocampus of Fe+++-induced epilepsy model : the methodology of in vivo microdialysis applied to ESR and the protective system against the pyramidal cell death in the hippocampus","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-08-04"},"publish_date":"2009-08-04","publish_status":"0","recid":"1398","relation_version_is_last":true,"title":["鉄塩誘導てんかんモデルラットの無麻酔自由行動条件下における海馬抗酸化能力の減弱 : 無麻酔自由行動条件下でのX-band ESRを用いた検討"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2024-12-03T06:52:12.681209+00:00"}