{"created":"2023-05-15T09:57:30.423872+00:00","id":1326,"links":{},"metadata":{"_buckets":{"deposit":"f2eefb13-b768-4a19-aabb-20a51086aeb0"},"_deposit":{"created_by":5,"id":"1326","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"1326"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00001326","sets":["72","72:30"]},"author_link":["7830","7846","7859"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"九州リウマチ","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"関節リウマチ（RA）の病態が徐々に解明されるに伴い治療の標的（細胞,分子）が明らかになり,さらにモノクローナル抗体作製技術の進歩やリコンビナントプロテイン作製など遺伝子工学技術の進歩により新しい薬剤が開発されてきている。現在,生物学的製剤の標的サイトカインとしてTFN-α（tumor necrosis factor alfa）,IL-1（interleukin-1）,IL-6が注目を浴びており,本邦でも抗TNF-α抗体が使用可能となり,臨床成績が報告されるようになった。本稿では,現在,実用前ではあるが今後期待されるその他のターゲッティング療法についてそれぞれの標的ごとにその内容と現状を述べる。 \n\\nOver the years, significant progress has been made in understanding the pathogenesis of rheumatoid arthritis （RA）. Recently, the targets for its treatment have been identified. Advancement of technologies utilizing monoclonal antibodies and recombinant proteins has allowed the development of novel drugs that effectively target the disease. Tumor necrosis factor alpha （TNF a）, interleukin-l （IL-I）, and IL-6 are notable therapeutic targets for RA. Recently, anti-TNF a antibodies used to treat RA were approved for use in Japan and results of clinical studies have been reported. In this report, the current context and state of each target cell or molecule are described. We also discuss other targeting therapies that are expected in the future, such as adhesion molecules, T-cell and B-cell surface antigens, osteoclastogenesis inhibitory factors, signal transduction pathways, angiogenic factors, and novel peptides.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"九州リウマチ学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00250490","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02872803","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"帖佐, 悦男","creatorNameLang":"ja"},{"creatorName":"チョウサ, エツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Chosa, Etsuo","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"関本, 朝久","creatorNameLang":"ja"},{"creatorName":"セキモト, トモヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Sekimoto, Tomohisa","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"濱田, 浩朗","creatorNameLang":"ja"},{"creatorName":"ハマダ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamada, Hiroaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"関本, 朝久","creatorNameLang":"ja"},{"creatorName":"セキモト, トモヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Sekimoto, Tomohisa","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"濱田, 浩朗","creatorNameLang":"ja"},{"creatorName":"ハマダ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamada, Hiroaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"1946.pdf","filesize":[{"value":"324.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1946.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/1326/files/1946.pdf"},"version_id":"e8a4aa28-0990-44e8-a805-172ca394c7ac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"rheumatoid arthritis, targeting therapy, biologic drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"関節リウマチ(RA)に対する新しいターゲティング療法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"関節リウマチ(RA)に対する新しいターゲティング療法","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"5","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-10"},"publish_date":"2009-03-10","publish_status":"0","recid":"1326","relation_version_is_last":true,"title":["関節リウマチ(RA)に対する新しいターゲティング療法"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2024-01-30T04:28:32.072809+00:00"}