2026-03-10T12:33:38Z https://miyazaki-u.repo.nii.ac.jp/oai

oai:miyazaki-u.repo.nii.ac.jp:00000282 2025-07-23T10:14:44Z 74 74:26

Peripheral Neuroblastoma and Primitive Neuroectodermal Tumor in Japanese Black Cattle 黒毛和牛の末梢性神経芽腫と未分化神経外胚様腫瘍 内田, 和幸 939 ウチダ, カズユキ Uchida, Kazuyuki 村上, 隆之 1255 ムラカミ, タカユキ Murakami, Takayuki 遠目塚, 敏夫 1256 トオメツカ, トシオ 岩切, 章 1257 イワキリ, アキラ Yamaguchi, Ryoji 940 山口, 良二 90150169 ヤマグチ, リョウジ 立山, 晉 937 タテヤマ, ススム Tateyama, Susumu Tometsuka, Toshio 1262 Iwakiri, Akira 1263 bovine, peripheral neuroblastoma, primitive neuroectodermal tumor (PNET) Peripheral neuroblastoma was found in a 1-year-old, male, Japanese black cattle （Case 1） and primitive neuroectodermal tumor was noted in 7-year-old, female, Japanese black cattle （Case 2）. In Case 1, neoplastic tissue was replaced the right cranial vault and nasopharynx. A large, soft mass approximately 18 cm in diameter was also observed in the right mandibulopharyngeal area. In Case 2, a neoplastic mass of about 15 cm in diameter was found in the mandibulopharygeal area. Histopathologically, massive necrosis showing a pseudopalisade arrangement was frequently observed in Case 1. On the contrary, Homer & Wright rosette formations of tumor cells were prominent in Case 2. Immunohistochemically, the proliferating cells in Case I were positive for vimentin, S-100, and neurofilament （NF） and those in Case 2 showed intense immunoreactivity for NF and neuron specific enolase, but were negative for vimentin and S-100. The different degrees of differentiation of the neoplastic cells originating from the neuroectoderm, might be reflected in their different morphological and immunohistochemical features. 黒毛和牛に認められた末梢性神経芽種と未分化神経外胚葉腫瘍を病理学的に比較検索した.症例1は1歳の雄牛で, 腫瘍組識が右側頭蓋腔と副鼻腔を置換し, 右側下顎部には直径約18cmの脆弱腫瘤の形成を認めた.症例2は7歳の雌牛で, 剖検時に直径約15cmの腫瘤が下顎部に認められた.病理組識学的に症例1では腫瘍細胞のPseudopalisade配列を伴う著明な壊死巣形成がみられ, 一方, 症例2ではHomer & Wright型のロゼット形成が顕著であった.免疫組識化学的には, 症例1の腫瘍細胞はVimentin, S-100, およびニューロフィラメントに陽性を示し, 症例2の腫瘍細胞はニューロフィラメントと神経特異エノラーゼに陽性で, Vimentin, S-100には陰性を示した.このような2症例間における相違は腫瘍細胞の分化度の差異を反映しているのではないかと思われた. Japanese Society of Veterinary Science 日本獣医学会 1998-07-25 VoR journal article application/pdf The journal of veterinary medical science 7 60 871 875 AA10796138 09167250 https://miyazaki-u.repo.nii.ac.jp/record/282/files/jvms60-7-871.pdf http://hdl.handle.net/10458/1174 https://miyazaki-u.repo.nii.ac.jp/records/282 eng http://ci.nii.ac.jp/naid/110003918514/ 日本獣医学会 本文データは学協会の許諾に基づきCiNiiから複製したものである