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Reciprocal contribution of pentraxin 3 and C-reactive protein to obesity and metabolic syndrome Ogawa, Tsuneo Kawano, Yurika 今村, 卓郎 イマムラ, タクロウ Imamura, Takuroh 今村 イマムラ Imamura 卓郎 タクロウ Takuroh Kawakita, Kumiko Sagara, Mina Matsuo, Takeshi Kakitsubata, Yousuke Ishikawa, Tadashi 50204912 北村, 和雄 キタムラ, カズオ Kitamura, Kazuo 北村 キタムラ Kitamura 和雄 カズオ Kazuo 宮崎大学 University of Miyazaki Hatakeyama, Kinta 70202588 Asada, Yujiro 浅田, 祐士郎 アサダ　, ユウジロウ Asada 浅田 アサダ Yujiro 祐士郎 ユウジロウ Kodama, Tatsuhiko metadata only access Pentraxin 3 （PTX3） is an acute-phase protein that shares structural homology with C-reactive protein （CRP）. PTX3 is produced in macrophages, endothelial cells, and adipocytes in response to inflammatory stimuli, whereas hepatocytes are the main source of CRP. Because obesity and metabolic syndrome （MetS） are considered chronic inflammatory states, PTX3 might be involved in the pathogenesis of obesity and MetS as well as CRP. Levels of CRP correlated positively with body weight, BMI, waist circumference （WC）, fasting plasma glucose and interleukin （IL）-6, and negatively with high-density lipoprotein cholesterol and adiponectin in healthy males. In contrast, PTX3 correlated positively with adiponectin, and negatively with body weight, BMI, WC, and triglyceride. Plasma CRP significantly increased, whereas plasma PTX3 significantly decreased with increasing BMI. Plasma CRP and PTX3 levels were significantly higher and lower, respectively, in individuals who had more than one MetS component compared with those who had none. In conclusion, PTX3 and CRP antagonistically participate in the development of obesity or MetS. 2010-09 eng journal article http://hdl.handle.net/10458/3585 https://miyazaki-u.repo.nii.ac.jp/records/1622 20111016 19307381 Obesity 18 9 1871 1874