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Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans Sato, Y. Hatakeyama, K. Yamashita, A. Marutsuka, K. Sumiyoshi, A. 70202588 Asada, Yujiro 浅田, 祐士郎 アサダ　, ユウジロウ Asada 浅田 アサダ Yujiro 祐士郎 ユウジロウ thrombus, acute myocardial infarction, fibrin, platelet Objective: To determine the proportion of platelets and fibrin in coronary thrombi. Design: Immunohistochemical and morphometric means to examine the coronary arteries of 31 patients who died of acute myocardial infarction. Results: Fresh thrombi were detected in the feeding arteries of infarction areas in 23 cases （74%） and were associated with plaque rupture in 18 （78%） and plaque erosion in 5 （22%）. An immunohistochemical study showed that the thrombi consisted of a mixture of fibrin and platelets as well as some other types of blood cells. The fibrin and platelet positive areas in the thrombi associated with plaque rupture accounted for 74 （19）% and 35 （20）% （p < 0.01） and those associated with erosion accounted for 51 （6）% and 70 （21）%, respectively, of the total areas. Areas of positive immunoreactivity for tissue factor and C reactive protein were also significantly greater in ruptured than in eroded plaques. Conclusion: These results indicate that the proportions of fibrin and of platelets differ in coronary thrombi on ruptured and eroded plaques. Higher proportions of tissue factor and C reactive protein contribute more significantly to thrombus formation on plaque rupture than on plaque erosion. BMJ Publishing Group 2005-04 eng journal article VoR http://hdl.handle.net/10458/1379 https://miyazaki-u.repo.nii.ac.jp/records/1617 AA11059124 13556037 Heart 91 4 526 530 https://miyazaki-u.repo.nii.ac.jp/record/1617/files/asada_heart_91-4-2005.pdf application/pdf 389.7 kB 2020-06-21