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Intrauterine infusion of povidone-iodine: Its effect on the endometrium and subsequent fertility in postpartum dairy cows 吉田, 留美加 ヨシダ, ルミカ Yoshida, Rumika 吉田 ヨシダ Yoshida 留美加 ルミカ Rumika 90523415 北原, 豪 キタハラ, ゴウ Kitahara, Go 北原 キタハラ Kitahara 豪 ゴウ Go 宮崎大学 University of Miyazaki 90302059 大澤, 健司 オオサワ, タケシ Osawa, Takeshi 大澤 オオサワ Osawa 健司 タケシ Takeshi 宮崎大学 University of Miyazaki open access ©2020 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) cattle cytology histopathology polymorphonuclear neutrophils povidone-iodine This study aimed to describe the duration of inflammation after intrauterine infusion of polyvinylpyrrolidone-iodine (povidone-iodine, PVP-I), determine the effect of PVP-I infusion on the subsequent fertility, and evaluate the histopathology of the endometrium in dairy cows. In Experiment 1, 120 lactating clinically healthy Holstein-Friesian cows at 5 weeks postpartum (W5) were equally divided into three groups: intrauterine infusion of 2% PVP-I (PVP), saline (SAL), and no treatment (NTX). Endometrial cytology was performed daily from D0 (W5) to D7 to determine the percentage of polymorphonuclear cells (PMN%) in 44 of the 120 cows. All cows received timed artificial insemination at D17. In Experiment 2, 25 cows were randomly classified into sacrifice at 24 hr or 48 hr after 2% PVP-I infusion (PVP24 and PVP48), and 24, 48, 72, or 96 hr after SAL infusion (SAL24; SAL48; SAL72; SAL96), or no treatment (NTX). Histopathology was performed on the uterus of each cow. In Experiment 1, PMN% was greater in PVP (P<0.05) than in SAL and NTX, on D1, but decreased to a level similar to that of the other groups by D2. Conception rate was higher (P<0.05) in PVP cows compared to SAL and NTX cows. In Experiment 2, stratified columnar epithelium in the uterus disappeared in PVP24 and SAL24. The epithelium was regenerated in PVP48, SAL72, and SAL96, but not in SAL48. In conclusion, the results of the study suggest that PVP-I induces transient uterine inflammation, promotes regeneration of endometrial epithelial cells and improves fertility. Citation: Rumika YOSHIDA, Go KITAHARA, Takeshi OSAWA, Intrauterine infusion of povidone-iodine: Its effect on the endometrium and subsequent fertility in postpartum dairy cows, Journal of Veterinary Medical Science, 2020, Volume 82, Issue 7, Pages 926-934, Released on J-STAGE July 10, 2020, Advance online publication May 20, 2020, Online ISSN 1347-7439, Print ISSN 0916-7250, https://doi.org/10.1292/jvms.20-0165 Japanese Society of Veterinary Science 2020 eng journal article VoR http://hdl.handle.net/10458/0002000150 https://miyazaki-u.repo.nii.ac.jp/records/2000150 https://doi.org/10.1292/jvms.20-0165 0916-7250 Journal of Veterinary Medical Science 82 7 926 934 https://miyazaki-u.repo.nii.ac.jp/record/2000150/files/82_20-0165.pdf application/pdf 2.1 MB 2023-10-26