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SIV/HIVキメラウイルスより構築されたvprベクターの性状
http://hdl.handle.net/10458/2881
http://hdl.handle.net/10458/2881e6491d1b-19dc-4dfe-bcce-75f638469fd5
名前 / ファイル | ライセンス | アクション |
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2881haga.pdf (62.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-05-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characterization of vpr Vector Constructed from Chimeric Simian and Human Immunodeficiency Virus | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | SIV/HIVキメラウイルスより構築されたvprベクターの性状 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | SHIV, vector, vpr | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
芳賀, 猛
× 芳賀, 猛× 大古場, 正史× 山崎, 奈々瀬× 隈部, 志野× 清水, 佑也× 後藤, 義孝× 桑田, 岳夫× コズレフ, ユーリ× 速水, 正憲× 三浦, 智行× Okoba, Masashi× Yamazaki, Nanase× Kumabe, Shino× Shimizu, Yuya× Kuwata, Takeo× Kozyrev, Iouri L.× 速水, 正憲× Miura, Tomoyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chimeric simian and human immunodeficiency viruses (SHIVs) are useful tool for investigating AIDS pathogenesis and for development of vaccine. We constructed a SHIV-vpr vector (designated as SHIV-3sj) by replacing vpr region with restriction enzyme sites. SHIV-3sj was designed to express inserted gene along with its viral replication. Five cytokine genes were inserted into SHIV-3sj, and ability of viral replication and expression of the inserted genes were examined. The short insert including RANTES and IL-5 resulted in the successful expression from SHIV-3sj, while the construct having longer genes including IL-2, IL-6 and IL-12p35 failed to become replication competent. These results suggest that the length of the insert is an important factor for the replication ability of SHIV-3sj vector. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | SIV/HIVキメラウイルス(SHIV)のvpr領域を制限酵素サイトに置換し,SHIV-3sjベクターを作成した.5種のサイトカイン遺伝子をSHIV3sjに挿入した結果,RANTESやIL-5といった短い遺伝子は発現が確認されたが,IL-2,IL-6,IL-12p35といった長い遺伝子を挿入したものは複製能を欠いた.挿入遺伝子の長さがSHIV-3sjベクターの複製を規定している可能性が示唆された. | |||||
言語 | ja | |||||
書誌情報 |
en : The journal of veterinary medical science en : Journal of veterinary medical science 巻 65, 号 5, p. 633-636, 発行日 2003-05-25 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Japanese Society of Veterinary Science | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 日本獣医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09167250 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13477439 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10796138 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 12808218 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |