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Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats
http://hdl.handle.net/10458/5416
http://hdl.handle.net/10458/541678740517-c222-488b-8d30-860f64069561
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | Blonanserin, Haloperidol, Latent inhibition, Immediate-early gene protein, Schizophrenia | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
著者 |
倉増, 亜紀
× 倉増, 亜紀× 安部, 博史× 小金丸, 剛× 松尾, 寿栄× 池田, 哲也× 蛯原, 功介× 船橋, 英樹× 武田, 龍一郎× 西森, 利數× 石田, 康 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To clarify the psychopharmacological profile of blonanserin, a novel antipsychotic, we examined its effect on the methamphetamine-induced disruption of latent inhibition (LI) and the neural activation related to this effect in rats. To evaluate the LI, we used a conditioned emotional response in which a tone (conditioned stimulus) was paired with a mild foot shock (unconditioned stimulus). This paradigm was presented to rats licking water. Methamphetamine-induced (1.0 mg/kg, i.p.) disruption of LI was significantly improved by the administration of a higher dose (3.0 mg/kg, i.p.) of blonanserin and tended to be improved by 1.0-mg/kg blonanserin and 0.2-mg/kg haloperidol but not by a lower dose (0.3 mg/kg) of blonanserin. Immunohistochemical examination showed blonanserin (3.0 mg/kg, i.p.) increased c-Fos expression in the shell area but not in the core area of the nucleus accumbens while methamphetamine (3.0 mg/kg, i.p.) produced the opposite expression pattern. Blonanserin also increased the number of c-Fos expressions in the central amygdala nucleus but not in the basolateral amygdala nucleus or the prefrontal cortex. Blonanserin ameliorates the methamphetamine-induced disruption of LI, as other antipsychotics do, and a neuronal activation and/or modulation of neurotransmission in the nucleus accumbens is related to the disruption of LI by methamphetamine and to its amelioration by blonanserin. | |||||
言語 | en | |||||
書誌情報 |
en : Neuroscience Letters 巻 549, p. 97–102-97–102, 発行日 2013-08 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier Ireland | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03043940 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.neulet.2013.06.020 | |||||
著者版フラグ | ||||||
出版タイプ | NA |