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鉄塩誘導てんかんモデルラットの無麻酔自由行動条件下における海馬抗酸化能力の減弱 : 無麻酔自由行動条件下でのX-band ESRを用いた検討
http://hdl.handle.net/10458/2140
http://hdl.handle.net/10458/21409d16c61e-28f8-4f2b-b7f2-45741f4bf249
名前 / ファイル | ライセンス | アクション |
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2-17b_ueda-jiki-vol.11-2000.pdf (332.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-08-04 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 鉄塩誘導てんかんモデルラットの無麻酔自由行動条件下における海馬抗酸化能力の減弱 : 無麻酔自由行動条件下でのX-band ESRを用いた検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Anti-oxydant ability in the hippocampus of Fe+++-induced epilepsy model : the methodology of in vivo microdialysis applied to ESR and the protective system against the pyramidal cell death in the hippocampus | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | Epilepsy, ESR, nitroxide radical, in vivo microdialysis, anti-oxydant ability | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
土井, 拓
× 土井, 拓× 植田, 勇人× 中島, 暉× 横山, 秀克× 徳丸, 潤× 三山, 吉夫× 保田, 昌秀× 大矢, 博明× 鎌田, 仁 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To analyze the hippocampal anti-oxydant ability in the Fe-induced epilepsy model, microdialysis was used to monitor the sequential changes of an exogenous nitroxide radical by X-band ESR in the freely moving rats. Nitroxide radicals used in this study are 200mM 3-methoxy carbonyl-2,2,5,5-tetramethylpyrrolidine-l-oxyl (PCAM) i.p. administration and 300mM 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-l-oxyl(carbamoyl-PROXYL) perfusated into the hippocampus for 70 min at 3ul/min. Each half-life of carbamoyl-PROXYL and PCAM in the epilepsy model was statistically longer than that of control, respectively. Prolonged half-life of carbamoyl-PROXYL reveals the decreased antioxydant ability in the extracellular space (ascorbic acid), while prolonged half-life of PCAM indicates the decreased anti-oxydant ability in the neuronal membrane (ascorbic acid and α-tocopherol). The result of the decreased hippocampal anti-oxydant ability is possibly due to lipid peroxidation induced by the repetitive seizures, and the decreased aniti-oxydant ability will results in the more severe damage in the pyramidal cell of the hippocampus. | |||||
言語 | en | |||||
書誌情報 |
ja : 磁気共鳴と医学 巻 11, p. 67-70, 発行日 2000 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 日本医学館 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Magnetic resonance in medicine | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10217072 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |