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Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death
http://hdl.handle.net/10458/1126
http://hdl.handle.net/10458/1126cd2b5e0b-9185-476d-9618-7dbb70ac5b40
名前 / ファイル | ライセンス | アクション |
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EJP-2006.pdf (547.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | Shiga toxin, p38 MAPK, tyrosine kinase, tyrosine kinase inhibitor, tyrphostin 47 | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
池田, 正浩
× 池田, 正浩× 伊藤, 勝昭× Gunji, Yasuhiro× 園田, 紘子× Oshikawa, Sayaka× Shimono, Mariko× Horie, Atsuko× 伊藤, 勝昭× Yamasaki, Shinji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The inhibitory effects of tyrosine kinase inhibitors including tyrphostin 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostin 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases. |
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言語 | en | |||||
書誌情報 |
en : European journal of pharmacology 巻 546, 号 1-3, p. 36-39, 発行日 2006-09-28 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00142999 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00639687 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/wps/find/journaldescription.cws_home/506087/description | |||||
関連名称 | http://www.elsevier.com/wps/find/journaldescription.cws_home/506087/description | |||||
著者版フラグ | ||||||
出版タイプ | AM |