The inhibitory effects of tyrosine kinase inhibitors including tyrphostin 25, 47 and 51 on
Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK)
phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga
toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostin 25 and 51
had no significant effect on the Shiga toxin 1-induced responses. These data indicate that
Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the
target molecule for tyrphostin 47 opens up new opportunities for pharmacological
intervention against Shiga toxin-producing Escherichia coli infectious diseases.
リポジトリのご案内
Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death
EJP-2006.pdf
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