WEKO3
アイテム
{"_buckets": {"deposit": "fd0f74ee-231e-4a4d-9b34-268f20e6be5e"}, "_deposit": {"created_by": 5, "id": "4586", "owners": [5], "pid": {"revision_id": 0, "type": "depid", "value": "4586"}, "status": "published"}, "_oai": {"id": "oai:miyazaki-u.repo.nii.ac.jp:00004586", "sets": ["76", "64"]}, "author_link": ["9050", "24686", "24525", "24680", "8704", "24524", "24528", "8383"], "control_number": "4586", "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-09", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "206–216", "bibliographicPageStart": "206–216", "bibliographicVolumeNumber": "277", "bibliographic_titles": [{"bibliographic_title": "Neuroscience", "bibliographic_titleLang": "en"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Hemokinin-1 (HK-1) is a new mammalian tachykinin peptide consisting of the amino acid sequence similar to substance P (SP). Although the function of SP, a representative tachykinin peptide, has been well established in the pain system, that of HK-1 has not yet been elucidated. [Leu^\u003c11\u003e]-SP had an antagonistic effect on SP-induced scratching behavior, suggesting that [Leu^\u003c11\u003e]-HK-1 may also attenuate the induction of scratching behavior by HK-1. Thus, the effects of a pretreatment with [Leu^\u003c11\u003e]-HK-1 were evaluated to clarify the function of HK-1. The intrathecal administration of [Leu^\u003c11\u003e]-HK-1 attenuated the induction of scratching by HK-1, but not SP, while [Leu^\u003c11\u003e]-SP reduced the induction of scratching by SP, but not HK-1. These results indicated that [Leu^\u003c11\u003e]-HK-1 may be a more specific antagonist of HK-1-preferred receptors and [Leu^\u003c11\u003e]-SP has an antagonistic effect on the SP-preferred receptor, the neurokinin 1 receptor. In the formalin test for examining noxious response, the intrathecal administration of [Leu^\u003c11\u003e]-SP, but not [Leu^\u003c11\u003e]-HK-1, reduced the number of flinchings and c-Fos-positive cells in the spinal dorsal horn following formalin injection into the plantar region of the hind paw. These results indicated that SP, but not HK-1, is involved in nociceptive processing at the spinal level. To evaluate the involvement of HK-1 and SP in pruritic processing, the effect of [Leu^\u003c11\u003e]-HK-1 and [Leu^\u003c11\u003e]-SP on the induction of scratching behavior and c-Fos expression by serotonin (5-HT) and histamine was evaluated. The increased induction of scratching behavior and c-Fos expression by 5-HT and histamine was markedly attenuated by pretreatment with both [Leu^\u003c11\u003e]-HK-1 and [Leu^\u003c11\u003e]-SP, suggesting that HK-1 and SP may be involved in pruritic processing. These results indicate that HK-1 is involved in pruritic processing and [Leu^\u003c11\u003e]-HK-1 is a valuable tool for clarifying the mechanisms underlying pruritic processing.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "International Brain Research Organization", "subitem_publisher_language": "en"}, {"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.neuroscience.2014.07.001", "subitem_relation_type_select": "DOI"}}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03064522", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_25": {"attribute_name": "BIBID", "attribute_value_mlt": [{"subitem_text_value": "TC10126801"}]}, "item_10001_textarea_24": {"attribute_name": "来歴", "attribute_value_mlt": [{"subitem_textarea_language": "ja", "subitem_textarea_value": "船橋 英樹博士学位論文(医学獣医学研究科甲第15号)許諾書受領"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Funahashi, Hideki", "creatorNameLang": "en"}, {"creatorName": "船橋, 英樹", "creatorNameLang": "ja"}, {"creatorName": "フナハシ, ヒデキ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Funahashi", "familyNameLang": "en"}, {"familyName": "船橋", "familyNameLang": "ja"}, {"familyName": "フナハシ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Hideki", "givenNameLang": "en"}, {"givenName": "英樹", "givenNameLang": "ja"}, {"givenName": "ヒデキ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "9050", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Naono-Nakayama, Rumi", "creatorNameLang": "en"}], "familyNames": [{"familyName": "Naono-Nakayama", "familyNameLang": "en"}], "givenNames": [{"givenName": "Rumi", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24686", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "蛯原, 功介", "creatorNameLang": "ja"}, {"creatorName": "エビハラ, コウスケ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Ebihara, Kosuke", "creatorNameLang": "en"}], "familyNames": [{"familyName": "蛯原", "familyNameLang": "ja"}, {"familyName": "エビハラ", "familyNameLang": "ja-Kana"}, {"familyName": "Ebihara", "familyNameLang": "en"}], "givenNames": [{"givenName": "功介", "givenNameLang": "ja"}, {"givenName": "コウスケ", "givenNameLang": "ja-Kana"}, {"givenName": "Kosuke", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24525", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "小金丸, 剛", "creatorNameLang": "ja"}, {"creatorName": "コガネマル, ゴウ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Koganemaru, Go", "creatorNameLang": "en"}], "familyNames": [{"familyName": "小金丸", "familyNameLang": "ja"}, {"familyName": "コガネマル", "familyNameLang": "ja-Kana"}, {"familyName": "Koganemaru", "familyNameLang": "en"}], "givenNames": [{"givenName": "剛", "givenNameLang": "ja"}, {"givenName": "ゴウ", "givenNameLang": "ja-Kana"}, {"givenName": "Go", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24680", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "倉増, 亜紀", "creatorNameLang": "ja"}, {"creatorName": "クラマシ, アキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Kuramashi, Aki", "creatorNameLang": "en"}], "familyNames": [{"familyName": "倉増", "familyNameLang": "ja"}, {"familyName": "クラマシ", "familyNameLang": "ja-Kana"}, {"familyName": "Kuramashi", "familyNameLang": "en"}], "givenNames": [{"givenName": "亜紀", "givenNameLang": "ja"}, {"givenName": "アキ", "givenNameLang": "ja-Kana"}, {"givenName": "Aki", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8704", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "池田, 哲也", "creatorNameLang": "ja"}, {"creatorName": "イケダ, テツヤ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Ikeda, Tetsuya", "creatorNameLang": "en"}], "familyNames": [{"familyName": "池田", "familyNameLang": "ja"}, {"familyName": "イケダ", "familyNameLang": "ja-Kana"}, {"familyName": "Ikeda", "familyNameLang": "en"}], "givenNames": [{"givenName": "哲也", "givenNameLang": "ja"}, {"givenName": "テツヤ", "givenNameLang": "ja-Kana"}, {"givenName": "Tetsuya", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24524", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishimori, Toshikazu", "creatorNameLang": "en"}, {"creatorName": "西森, 利數", "creatorNameLang": "ja"}, {"creatorName": "ニシモリ, トシカズ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Nishimori", "familyNameLang": "en"}, {"familyName": "西森", "familyNameLang": "ja"}, {"familyName": "ニシモリ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Toshikazu", "givenNameLang": "en"}, {"givenName": "利數", "givenNameLang": "ja"}, {"givenName": "トシカズ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "24528", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20112211", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20112211"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "Ishida, Yasushi", "creatorNameLang": "en"}, {"creatorName": "石田, 康", "creatorNameLang": "ja"}, {"creatorName": "イシダ, ヤスシ", "creatorNameLang": "ja-Kana"}], "familyNames": [{"familyName": "Ishida", "familyNameLang": "en"}, {"familyName": "石田", "familyNameLang": "ja"}, {"familyName": "イシダ", "familyNameLang": "ja-Kana"}], "givenNames": [{"givenName": "Yasushi", "givenNameLang": "en"}, {"givenName": "康", "givenNameLang": "ja"}, {"givenName": "ヤスシ", "givenNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "8383", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20212897", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20212897"}]}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "pruritus, serotonin, histamine, [Leu^\u003c11\u003e]-hemokinin-1, spinal cord, rat", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hemokinin-1 mediates pruriceptive processing in the rat spinal cord", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Hemokinin-1 mediates pruriceptive processing in the rat spinal cord", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "5", "path": ["76", "64"], "permalink_uri": "http://hdl.handle.net/10458/5435", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-06-21"}, "publish_date": "2020-06-21", "publish_status": "0", "recid": "4586", "relation": {}, "relation_version_is_last": true, "title": ["Hemokinin-1 mediates pruriceptive processing in the rat spinal cord"], "weko_shared_id": -1}
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord
http://hdl.handle.net/10458/5435
http://hdl.handle.net/10458/54353a85e1c6-01f5-46c5-b55d-f4e440e3de3f
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-06-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Hemokinin-1 mediates pruriceptive processing in the rat spinal cord | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | pruritus, serotonin, histamine, [Leu^<11>]-hemokinin-1, spinal cord, rat | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
著者 |
船橋, 英樹
× 船橋, 英樹× Naono-Nakayama, Rumi× 蛯原, 功介× 小金丸, 剛× 倉増, 亜紀× 池田, 哲也× 西森, 利數× 石田, 康 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hemokinin-1 (HK-1) is a new mammalian tachykinin peptide consisting of the amino acid sequence similar to substance P (SP). Although the function of SP, a representative tachykinin peptide, has been well established in the pain system, that of HK-1 has not yet been elucidated. [Leu^<11>]-SP had an antagonistic effect on SP-induced scratching behavior, suggesting that [Leu^<11>]-HK-1 may also attenuate the induction of scratching behavior by HK-1. Thus, the effects of a pretreatment with [Leu^<11>]-HK-1 were evaluated to clarify the function of HK-1. The intrathecal administration of [Leu^<11>]-HK-1 attenuated the induction of scratching by HK-1, but not SP, while [Leu^<11>]-SP reduced the induction of scratching by SP, but not HK-1. These results indicated that [Leu^<11>]-HK-1 may be a more specific antagonist of HK-1-preferred receptors and [Leu^<11>]-SP has an antagonistic effect on the SP-preferred receptor, the neurokinin 1 receptor. In the formalin test for examining noxious response, the intrathecal administration of [Leu^<11>]-SP, but not [Leu^<11>]-HK-1, reduced the number of flinchings and c-Fos-positive cells in the spinal dorsal horn following formalin injection into the plantar region of the hind paw. These results indicated that SP, but not HK-1, is involved in nociceptive processing at the spinal level. To evaluate the involvement of HK-1 and SP in pruritic processing, the effect of [Leu^<11>]-HK-1 and [Leu^<11>]-SP on the induction of scratching behavior and c-Fos expression by serotonin (5-HT) and histamine was evaluated. The increased induction of scratching behavior and c-Fos expression by 5-HT and histamine was markedly attenuated by pretreatment with both [Leu^<11>]-HK-1 and [Leu^<11>]-SP, suggesting that HK-1 and SP may be involved in pruritic processing. These results indicate that HK-1 is involved in pruritic processing and [Leu^<11>]-HK-1 is a valuable tool for clarifying the mechanisms underlying pruritic processing. | |||||
言語 | en | |||||
書誌情報 |
en : Neuroscience 巻 277, p. 206–216-206–216, 発行日 2014-09 |
|||||
出版者 | ||||||
言語 | en | |||||
出版者 | International Brain Research Organization | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03064522 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.neuroscience.2014.07.001 | |||||
著者版フラグ | ||||||
出版タイプ | NA |