To investigate which brain regions are involved in the anticipatory activity in rats restricted feeding for 2 hr, we examined c-Fos expression before and after feeding. Only the thalamic paraventricular nucleus (tPVN) showed c-Fos expression before feeding than after feeding. After the anticipatory locomotor activity rhythm was established, lesioning the tPVN attenuated this rhythm, but not the light-dark entrained rhythm. The anticipatory increase of blood corticosterone levels was not established in long-term tPVN-lesioned rats. These results suggest that the tPVN is involved in the expression of anticipatory reactions under a food-restricted regimen.
給餌時間を毎日定刻の2時間のみに制限すると,ラットは餌の来る時刻を予知し,予知行動を示すようになる.給餌時刻前後の脳内cFosの発現部位を調べた結果,視床室傍核に発現の差を認めた.そこで,この部位を電気破壊すると,予知行動のみ消失した.また,視床室傍核を破壊したラットでは,血中コルチコステロンの制限給餌直前のピークが形成されなかった.以上の結果は,視床室傍核が制限給餌で発動する予知行動に関与していることを示唆する.
リポジトリのご案内
Involvement of thalamic paraventricular nucleus in the anticipatory reaction under food restriction in the rat
JVMS66(10)1297.pdf
(624.5KB)
