A solitary brain mass of a 4-month-old miniature dachshund showing seizure-like neurological signs was examined histopathologically. At necropsy a white tumor mass, replacing the thalamus, approximately 1.5 cm in diameter, was found. There was cystic space filled with yellowish pale fluid in the central area of the tumor mass. Histopathological examination revealed that the mass consisted of irregularly arranged well-differentiated neuronal and glial cells, and multifocal mineral deposits. The neuronal cells had a large clear nucleus and various amount of Nissl substances in the cytoplasm. Some neural cells were bi-nucleated. Neither mitotic figures nor proliferating cell nuclear antigen (PCNA)-positive nuclei was found in the neuronal cells. Immunostaining for glial fibrillary acidic protein (GFAP) revealed diffuse proliferation of GFAP-positive glial cells and their processes, while these glial cells did not show apparent cellular atypism, mitotic activity, or PCNA-immunoreactivity. Accordingly, the present tumor was diagnosed as ganglioglioma, and hamartomatous histogenesis might be possible.
癲癇発作様の神経症状を呈した4ヶ月齢,雄,ミニチュア・ダックスフントの脳腫瘤を病理組織学的に検索した.肉眼的には,視床下部を置換する直径1.5cmの白色腫瘤が認められた.腫瘤中心部は不規則な嚢胞状で黄色淡明液が貯留していた.病理組織学的検索の結果,同腫瘤は不規則に配列した神経細胞,グリア細胞及び多巣状性ミネラル沈着により構成されていた.同部の神経細胞は,大型淡明核と様々な量のニッスル顆粒を有し,2核細胞もみられた.これらの神経細胞に核分裂像や増殖性細胞核抗原(PCNA)陽性核は認められなかった.グリア線維性酸性蛋白(GFAP)に対する免疫染色により,GFAP陽性グリア細胞及びその突起の瀰漫性増殖が確認されたが,これらの細胞にも明確な異型性,核分裂像,PCNA免疫反応はみられなかった.以上の所見より本腫瘤は神経節膠腫と診断され,過誤腫的組織発生の可能性も考えられた.
リポジトリのご案内
Ganglioglioma in the thalamus of a puppy
JVMS65(1)113.pdf
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