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脳内微小透析法によりラット線条体に投与されたニトロキシドラジカルのESR画像
http://hdl.handle.net/10458/2049
http://hdl.handle.net/10458/2049457647aa-3278-42b2-9692-2604bd0b8595
名前 / ファイル | ライセンス | アクション |
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ueda-jiki1997.pdf (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-06-26 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 脳内微小透析法によりラット線条体に投与されたニトロキシドラジカルのESR画像 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | ESR imaging of the rat brain with a nitroxide radical perfused by in vivo microdialysis | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | ESR-imaging system, in vivo ESR, Rat brain, Nitroxide radicals, Microdialysis | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
植田, 勇人
× 植田, 勇人× 横山, 秀克× 大矢, 博明× 鎌田, 仁 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We report here our investigation of the spatial distribution of free radicals using an electron spin resonance (ESR)-imaging system combined with an in vivo brain microdialysis method, which was performed in the resonator of the ESR-imaging system. A non-magnetic cannula, newly developed in this study, was used for the perfusion of the exogenous free radicals agent. A nitroxide, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-l-oxyl (carbamoyl PROYXL), was used as the imaging agent in- saline solution at a concentration of 0.3 M, which was perfused into the right caudate putamen of the rat at 2 ml/min by a microinfusion pump. Two-dimensional ESR projection of the Z-X plane, which was clearly distinguished (about 10 mm diameter) from the nonperfused brain area, was obtained 6 hours after the beginning of perfusion of carbamoyl PROXYL. The present method is considered to be a useful tool to introduce stable free radicals into a specific area of the brain. | |||||
言語 | en | |||||
書誌情報 |
ja : 磁気共鳴と医学 巻 8, p. 37-40, 発行日 1997-08 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 日本医学館 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Magnetic resonance in medicine | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10217072 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |